Phenotypes Associated with This Genotype

Genotype
MGI:5003466

• Allelic Composition: Gdf5^bp-H/Gdf5^bp-H
• Genetic Background: involves: PCT

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

abnormal limb morphology ( J:172114 )

• hind limb development is severely compromised compared with forelimb development

• anomalies are discernable at birth

abnormal femur morphology ( J:172114 )

• histological analysis shows growth is retarded, one third the rate of normal, until E15

• growth rate of a cultured femur is greatly retarded

short femur ( J:172114 )

• observed at birth

abnormal fibula morphology ( J:172114 )

• histological analysis shows growth of the fibula is retarded, one quarter of normal, until E16

• the cultured fibula of E13 embryos do not grow during 4 days of culture

short fibula ( J:172114 )

• observed at birth

abnormal tibia morphology ( J:172114 )

• histological analysis shows retarded growth, half the rate of normal, from E13 to E14

• growth rate of a cultured tibia approximates normal

short tibia ( J:172114 )

• observed at birth

skeleton

abnormal femur morphology ( J:172114 )

• histological analysis shows growth is retarded, one third the rate of normal, until E15

• growth rate of a cultured femur is greatly retarded

short femur ( J:172114 )

• observed at birth

abnormal fibula morphology ( J:172114 )

• histological analysis shows growth of the fibula is retarded, one quarter of normal, until E16

• the cultured fibula of E13 embryos do not grow during 4 days of culture

short fibula ( J:172114 )

• observed at birth

abnormal tibia morphology ( J:172114 )

• histological analysis shows retarded growth, half the rate of normal, from E13 to E14

• growth rate of a cultured tibia approximates normal

short tibia ( J:172114 )

• observed at birth

abnormal cartilage development ( J:172114 )

• shortened long bones are the result of retardation of growth and differentiation of cartilage cells formed from postaxial mesenchyme

abnormal endochondral bone ossification ( J:172114 )

• differentiation of the femur and fibula is retarded compared with normal development