Phenotypes Associated with This Genotype

Genotype
MGI:5006709

• Allelic Composition: Zbtb17^tm1Cksn/Zbtb17^tm1Cksn; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: B6.Cg-Zbtb17^tm1Cksn Commd10^{Tg(Vav1-icre)A2Kio}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased T cell apoptosis ( J:170508 )

• pro-T cells exhibit excessive cell death unlike wild-type cells

thymus hypoplasia ( J:170508 )

• 100-fold reduction in cellularity

arrested T cell differentiation ( J:170508 )

• early lymphoid progenitors and early thymic precursors fail to differentiate into mature T cells in the presence of Il7 unlike in wild-type mice

• however, inhibition of SOCS1 or overexpression of Bcl2 restores T cell differentiation in vitro

decreased T cell number ( J:170508 )

• alphabeta-T cells are reduced 1000-fold compared to in wild-type mice

decreased thymocyte number ( J:170508 )

• early T-cell precursors in the thymus are reduced compared to in wild-type mice

decreased DN1 thymic pro-T cell number ( J:170508 )

• DN1a-e subsets are decreased 70- to 130-fold compared to in wild-type mice

• DN1a/b cells are decreased 230-fold compared to in wild-type mice

decreased DN2 thymocyte number ( J:170508 )

• 100-fold reduction in DN2a cells

• 40-fold reduction in DN2b cells

decreased DN3 thymocyte number ( J:170508 )

• 3-fold reduction in DN3a cells

• 10-fold reduction in DN3b cells

decreased double-negative T cell number ( J:170508 )

decreased gamma-delta T cell number ( J:170508 )

• 7-fold

hematopoietic system

increased T cell apoptosis ( J:170508 )

• pro-T cells exhibit excessive cell death unlike wild-type cells

thymus hypoplasia ( J:170508 )

• 100-fold reduction in cellularity

arrested T cell differentiation ( J:170508 )

• early lymphoid progenitors and early thymic precursors fail to differentiate into mature T cells in the presence of Il7 unlike in wild-type mice

• however, inhibition of SOCS1 or overexpression of Bcl2 restores T cell differentiation in vitro

decreased T cell number ( J:170508 )

• alphabeta-T cells are reduced 1000-fold compared to in wild-type mice

decreased thymocyte number ( J:170508 )

• early T-cell precursors in the thymus are reduced compared to in wild-type mice

decreased DN1 thymic pro-T cell number ( J:170508 )

• DN1a-e subsets are decreased 70- to 130-fold compared to in wild-type mice

• DN1a/b cells are decreased 230-fold compared to in wild-type mice

decreased DN2 thymocyte number ( J:170508 )

• 100-fold reduction in DN2a cells

• 40-fold reduction in DN2b cells

decreased DN3 thymocyte number ( J:170508 )

• 3-fold reduction in DN3a cells

• 10-fold reduction in DN3b cells

decreased double-negative T cell number ( J:170508 )

decreased gamma-delta T cell number ( J:170508 )

• 7-fold

cellular

increased T cell apoptosis ( J:170508 )

• pro-T cells exhibit excessive cell death unlike wild-type cells

endocrine/exocrine glands

thymus hypoplasia ( J:170508 )

• 100-fold reduction in cellularity

decreased thymocyte number ( J:170508 )

• early T-cell precursors in the thymus are reduced compared to in wild-type mice

decreased DN1 thymic pro-T cell number ( J:170508 )

• DN1a-e subsets are decreased 70- to 130-fold compared to in wild-type mice

• DN1a/b cells are decreased 230-fold compared to in wild-type mice

decreased DN2 thymocyte number ( J:170508 )

• 100-fold reduction in DN2a cells

• 40-fold reduction in DN2b cells

decreased DN3 thymocyte number ( J:170508 )

• 3-fold reduction in DN3a cells

• 10-fold reduction in DN3b cells