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Phenotypes Associated with This Genotype
Genotype
MGI:5006960
Allelic
Composition		 Atp11cambr/Y
Genetic
Background		 C57BL/6-Atp11cambr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp11cambr mutation (2 available); any Atp11c mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell differentiation ( J:171924 )
• B cell differentiation from pro-B cells into pre-B and immature cells is disrupted compared to in wild-type mice
• mice exhibit less transition of pro-B cells from immunoglobulin- to immunoglobulin+ cells compared with wild-type mice
decreased pro-B cell number ( J:171924 )
• in the bone marrow
decreased B cell number ( J:171924 )
• mice exhibit decreased B cell frequency in the blood, peritoneal cavity, and spleen compared with wild-type mice
decreased immature B cell number ( J:171924 )
• in the bone marrow and spleen
decreased mature B cell number ( J:171924 )
• in the bone marrow
decreased B-1 B cell number ( J:171924 )
• in the peritoneal cavity
decreased B-1a cell number ( J:171924 )
• in the peritoneal cavity
decreased B-1b cell number ( J:171924 )
• in the peritoneal cavity
decreased B-2 B cell number ( J:171924 )
• in the peritoneal cavity
decreased pre-B cell number ( J:171924 )
• in the bone marrow
decreased T cell number ( J:171924 )
• in the spleen
abnormal humoral immune response ( J:171924 )
• mice treated with inactivated Bordetella pertussis or alum-precipitated chicken gamma-globulin (CGG) coupled to the hapten azo-benzene-arsonate (ABA) exhibit reduced antibody response compared with wild-type mice
• booster immunization with ABA-CGG failed to produce anti-ABA antibodies unlike in wild-type mice
• however, antibody response to NP-Ficoll is normal

neoplasm
increased hepatocellular carcinoma incidence ( J:171924 )
• in all months at 6 months of age with areas of hemorrhage, necrosis, and hypervascularity

homeostasis/metabolism

hematopoietic system
hematopoietic system phenotype ( J:171924 )
N
• mice exhibit normal numbers of major blood cell progenitors and lineages in the bone marrow
abnormal B cell differentiation ( J:171924 )
• B cell differentiation from pro-B cells into pre-B and immature cells is disrupted compared to in wild-type mice
• mice exhibit less transition of pro-B cells from immunoglobulin- to immunoglobulin+ cells compared with wild-type mice
decreased pro-B cell number ( J:171924 )
• in the bone marrow
decreased B cell number ( J:171924 )
• mice exhibit decreased B cell frequency in the blood, peritoneal cavity, and spleen compared with wild-type mice
decreased immature B cell number ( J:171924 )
• in the bone marrow and spleen
decreased mature B cell number ( J:171924 )
• in the bone marrow
decreased B-1 B cell number ( J:171924 )
• in the peritoneal cavity
decreased B-1a cell number ( J:171924 )
• in the peritoneal cavity
decreased B-1b cell number ( J:171924 )
• in the peritoneal cavity
decreased B-2 B cell number ( J:171924 )
• in the peritoneal cavity
decreased pre-B cell number ( J:171924 )
• in the bone marrow
decreased T cell number ( J:171924 )
• in the spleen

liver/biliary system
increased hepatocellular carcinoma incidence ( J:171924 )
• in all months at 6 months of age with areas of hemorrhage, necrosis, and hypervascularity

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory