Phenotypes Associated with This Genotype

Genotype
MGI:5007621

• Allelic Composition: Fbxw7^tm1Itom/Fbxw7⁺; Tg(Pgk1-cre)1Lni/0
• Genetic Background: involves: 129 * BALB/c * C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:172214 )

• all pups die shortly after birth

respiratory system

impaired lung alveolus development ( J:172214 )

• disruption of the canalicular and /or terminal sac stage of lung development

thick pulmonary interalveolar septum ( J:172214 )

• thickened alveolar septa at E18.5

vision/eye

eyelids open at birth ( J:172214 )

• in 17 of 40 mice

craniofacial

cleft palate ( J:172214 )

• in 30% of mice

digestive/alimentary system

cleft palate ( J:172214 )

• in 30% of mice

growth/size/body

cleft palate ( J:172214 )

• in 30% of mice