Phenotypes Associated with This Genotype

Genotype
MGI:5009810

• Allelic Composition: B2m^tm1Jae/B2m^tm1Jae; Tap1^tm1Hpl/Tap1^tm1Hpl
• Genetic Background: B6.129-B2m^tm1Jae Tap1^tm1Hpl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

enlarged lateral ventricles ( J:66246 )

• 52% of P13 mice and 57% of adult mice have enlarged lateral ventricles

abnormal lateral geniculate nucleus morphology ( J:66246 )

• area of the ipsilateral projection is increased compared to controls

• in some cases, multiple ectopic clusters of inputs are present in the medial areas of the LGN

• retinogeniculate axons, glomeruli and bouton appear normal

abnormal synaptic bouton morphology ( J:120941 )

• increase in size of excitatory presynaptic boutons

abnormal synapse morphology ( J:120941 )

• mice exhibit significantly fewer perforations at hippocampal synapses that wild-type

abnormal synaptic vesicle number ( J:120941 )

• presynaptic nerve terminals contain 10% more synaptic vesicles than wild-type

enhanced long-term potentiation ( J:66246 )

• LTP in response to tetanus is enhanced by approximately 227% as compared to wild type

abnormal miniature excitatory postsynaptic currents ( J:120941 )

• 40% increase in frequency in hippocampal neurons

• 100% increase in frequency in layer 4 cortical neurons

• median amplitude is similar to wild-type in hippocampal and layer 4 neurons

• treatment with the neural activity blocker, Tetrodotoxin (TTX), does not increase mEPSC in mutant hippocampal cultures in contrast to increases in both amplitude and frequency observed in wild-type

abnormal long-term depression ( J:66246 )

• 900 pulses at 1 Hz enhances baseline LTD, but LTD is unchanged in wild-type

reduced long-term depression ( J:66246 )

• 900 pulses at 0.5 Hz does not induce significant LTD in contrast to wild-type response