Phenotypes Associated with This Genotype

Genotype
MGI:5013434

• Allelic Composition: Pax9^{tm1.1(Osr2)Jian}/Pax9^{tm1.1(Osr2)Jian}
• Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:173121 )

• mice die shortly after birth

craniofacial

abnormal craniofacial bone morphology ( J:173121 )

arrest of tooth development ( J:173121 )

• at bud stage

abnormal mandible morphology ( J:173121 )

• mice exhibit defects in the alveolar bone in the mandible compared with wild-type mice

absent mandibular coronoid process ( J:173121 )

small mandible ( J:173121 )

abnormal palatal shelf morphology ( J:173121 )

• at E13.5, the palatal shelves are broadened compared to in wild-type mice

palatal shelves fail to meet at midline ( J:173121 )

• at E15.5

cleft secondary palate ( J:173121 )

skeleton

abnormal craniofacial bone morphology ( J:173121 )

arrest of tooth development ( J:173121 )

• at bud stage

abnormal mandible morphology ( J:173121 )

• mice exhibit defects in the alveolar bone in the mandible compared with wild-type mice

absent mandibular coronoid process ( J:173121 )

small mandible ( J:173121 )

limbs/digits/tail

preaxial polydactyly ( J:173121 )

digestive/alimentary system

abnormal palatal shelf morphology ( J:173121 )

• at E13.5, the palatal shelves are broadened compared to in wild-type mice

palatal shelves fail to meet at midline ( J:173121 )

• at E15.5

cleft secondary palate ( J:173121 )

hearing/vestibular/ear

decreased tympanic ring size ( J:173121 )

growth/size/body

arrest of tooth development ( J:173121 )

• at bud stage

abnormal palatal shelf morphology ( J:173121 )

• at E13.5, the palatal shelves are broadened compared to in wild-type mice

palatal shelves fail to meet at midline ( J:173121 )

• at E15.5

cleft secondary palate ( J:173121 )