Phenotypes Associated with This Genotype

Genotype
MGI:5013464

• Allelic Composition: Tnfsf11^tm1Pngr/Tnfsf11^tm1Pngr
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal thymus epithelium morphology ( J:173115 )

• mice exhibit reduced percentage of UEA-1+ medullary thymic epithelial cells compared with wild-type mice

• mice exhibit reduced MHC II^high and MHC II^low medullary thymic epithelial cells (mTEC) compared with wild-type mice

• reduction of MHC II^high mTEC is more prominent compared with the reduction of MHC II^low mTEC

hematopoietic system

abnormal thymus epithelium morphology ( J:173115 )

• mice exhibit reduced percentage of UEA-1+ medullary thymic epithelial cells compared with wild-type mice

• mice exhibit reduced MHC II^high and MHC II^low medullary thymic epithelial cells (mTEC) compared with wild-type mice

• reduction of MHC II^high mTEC is more prominent compared with the reduction of MHC II^low mTEC

endocrine/exocrine glands

abnormal thymus epithelium morphology ( J:173115 )

• mice exhibit reduced percentage of UEA-1+ medullary thymic epithelial cells compared with wild-type mice

• mice exhibit reduced MHC II^high and MHC II^low medullary thymic epithelial cells (mTEC) compared with wild-type mice

• reduction of MHC II^high mTEC is more prominent compared with the reduction of MHC II^low mTEC