Phenotypes Associated with This Genotype

Genotype
MGI:5013822

• Allelic Composition: Tlr3^tm1Flv/Tlr3^tm1Flv
• Genetic Background: B6.129S1-Tlr3^tm1Flv/Apb

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal cytokine level ( J:129533 )

• reduced cytokine response 8 hours after poly I:C treatment as determined by TNF alpha, IL-6, IL12p40, and IFN-beta

abnormal interleukin level ( J:126415 )

• IL-13 is upregulated in the lungs after infection with Respiratory syncytial virus

• IL-5 is upregulated later in the infection response to Respiratory syncytial virus

delayed wound healing ( J:169762 )

• wound healing of full thickness circular skin opennings are markedly delayed

• full wound closure around 14 days rather than 12 days as in controls

• reduced infiltration of neutrophiles at days 1 and 3 and of macrophage at days 3 and 6

• reduced presence of chemokines involved in leukocyte recruitment

respiratory system

abnormal respiratory system physiology ( J:126415 )

• increased mucus in the lungs 6 days after infection

• antibody to IL13 attenuates the mucus response to Respiratory syncytial virus

nervous system

abnormal axon morphology ( J:127638 )

• number of axons in L1-L5 dorsal roots is unaffected by poly I:C treatment, unlike controls

abnormal neuron physiology ( J:127638 )

• isolated E14 dorsal root ganglion neurons are resistant to poly I:C inhibition of neurite outgrowth

behavior/neurological

abnormal righting response ( J:127638 )

• treatment of mice at 4 days of age has no effect on righting behavior at 9 days of age, unlike controls

neoplasm

increased tumor incidence ( J:158910 )

• implanted tumor cells grow larger than in controls

immune system

abnormal cytokine level ( J:129533 )

• reduced cytokine response 8 hours after poly I:C treatment as determined by TNF alpha, IL-6, IL12p40, and IFN-beta

abnormal interleukin level ( J:126415 )

• IL-13 is upregulated in the lungs after infection with Respiratory syncytial virus

• IL-5 is upregulated later in the infection response to Respiratory syncytial virus

decreased interferon-beta secretion ( J:251008 )

• in peritoneal macrophages stimulated with poly(I:C)