Phenotypes Associated with This Genotype

Genotype
MGI:5013824

• Allelic Composition: Usp4^tm1Xilu/Usp4^tm1Xilu
• Genetic Background: B6.129-Usp4^tm1Xilu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell physiology ( J:173192 )

• mouse embryonic fibroblasts (MEFs) exhibit growth retardation and resistance against oncogenic transformation compared with wild-type cells

increased cellular sensitivity to ionizing radiation ( J:173192 )

• in mouse embryonic fibroblasts

increased cellular sensitivity to ultraviolet irradiation ( J:173192 )

• in mouse embryonic fibroblasts

increased thymocyte apoptosis ( J:173192 )

• induced by irradiation

increased splenocyte apoptosis ( J:173192 )

• induced by irradiation

early cellular replicative senescence ( J:173192 )

• in mouse embryonic fibroblasts

hematopoietic system

increased thymocyte apoptosis ( J:173192 )

• induced by irradiation

increased splenocyte apoptosis ( J:173192 )

• induced by irradiation

immune system

increased thymocyte apoptosis ( J:173192 )

• induced by irradiation

increased splenocyte apoptosis ( J:173192 )

• induced by irradiation

endocrine/exocrine glands

increased thymocyte apoptosis ( J:173192 )

• induced by irradiation