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Phenotypes Associated with This Genotype
Genotype
MGI:5013920
Allelic
Composition		 Pdpk1tm1Maka/Pdpk1tm1Maka
Ptentm1Hwu/Ptentm1Hwu
Tg(Zp3-cre)93Knw/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdpk1tm1Maka mutation (0 available); any Pdpk1 mutation (138 available)
Ptentm1Hwu mutation (16 available); any Pten mutation (82 available)
Tg(Zp3-cre)93Knw mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:165798 )
N
• fertility of double mutant females is completely restored from 10-30 weeks of age when mated with wild-type males compared to single conditional homozygous Pdpk1 mutants
• embryos derived from double mutant females mated with wild-type males show normal perimplantation development, indicating rescue of the two-cell arrest and the suppressed embryonic genome activation seen in embryos from single conditional homozygous Pdpk1 mutants

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory