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Phenotypes Associated with This Genotype
Genotype
MGI:5014351
Allelic
Composition
ApcMin/Apc+
Gt(ROSA)26Sor/Gt(ROSA)26Sor+
Genetic
Background
B6.Cg-Gt(ROSA)26Sor ApcMin
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation (12 available); any Apc mutation (154 available)
Gt(ROSA)26Sor mutation (16 available); any Gt(ROSA)26Sor mutation (958 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• female mice treated with ENU survive for 86 days as compared to 66-71 days for mice carrying ApcMin alone
• female mice treated with ENU develop significantly fewer intestinal tumors than mice carrying either ApcMin alone or C57BL/6 controls
• female mice treated with ENU develop significantly fewer mammary tumors than mice carrying either ApcMin alone or C57BL/6 controls
• female mice treated with ENU develop significantly fewer mammary or intestinal tumors than mice carrying either ApcMin alone or C57BL/6 controls

homeostasis/metabolism
• female mice treated with ENU develop significantly fewer mammary or intestinal tumors than mice carrying either ApcMin alone or C57BL/6 controls

integument
• female mice treated with ENU develop significantly fewer mammary tumors than mice carrying either ApcMin alone or C57BL/6 controls

endocrine/exocrine glands
• female mice treated with ENU develop significantly fewer mammary tumors than mice carrying either ApcMin alone or C57BL/6 controls

digestive/alimentary system
• female mice treated with ENU develop significantly fewer intestinal tumors than mice carrying either ApcMin alone or C57BL/6 controls


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory