Phenotypes Associated with This Genotype

Genotype
MGI:5014514

• Allelic Composition: Pten^tm1Hwu/Pten^tm1Hwu; Tg(Nkx2-1-cre)2Sand/0
• Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:197590 )

N • Background Sensitivity: unlike on the congenic C57BL/6 background, mutants on the BALB/c background have normal T4 and TSH levels

decreased susceptibility to injury ( J:167962 )

• after naphthalene administration to induce lung injury, the proximal airway epithelium at 3 and 7 days post injury appears intact with no signs of injury

• after naphthalene administration to induce lung injury, the level of injury in the bronchial airway epithelium is reduced and repair is enhanced compared to controls

respiratory system

increased lung endothelial cell proliferation ( J:167962 )

• mutants exhibit an increase in the proliferation rate of the epithelial cells in E15.5 lungs

• expansion of epithelial cell populations occurs in multiple progenitor cell niches of the lungs including the tracheal basal cells in the proximal lung, the neuroepithelial bodies (NEB) in the distal bronchi and the progenitor cells occupying the bronchioalveolarduct junction (BADJ) region

abnormal lung morphology ( J:167962 )

• lungs exhibit increased cell proliferation and decreased apoptosis

• lungs at 8 weeks of age sometimes contain a mass consisting of epithelial cells (putative progenitor cell masses) around the BADJ area; masses are slow growing and are organized into ductlike structures

pulmonary hyperplasia ( J:167962 )

• progressive epithelial hyperplasia extending from the trachea to the small bronchioles is seen in the proximal lung epithelium from early stages of lung development and in adults

abnormal lung development ( J:167962 )

• marker analysis indicates a block in transition from precursor to terminally differentiated cell types indicating impaired epithelial cell fate determination in the lung

increased club cell number ( J:167962 )

• increase in number of Clara cells in the lungs and a decrease in the number of ciliated cells, the terminally differentiated progeny of Clara cells

cellular

increased lung endothelial cell proliferation ( J:167962 )

• mutants exhibit an increase in the proliferation rate of the epithelial cells in E15.5 lungs

• expansion of epithelial cell populations occurs in multiple progenitor cell niches of the lungs including the tracheal basal cells in the proximal lung, the neuroepithelial bodies (NEB) in the distal bronchi and the progenitor cells occupying the bronchioalveolarduct junction (BADJ) region

endocrine/exocrine glands

abnormal thyroid gland morphology ( J:197590 )

• Background Sensitivity: at P14, epithelial cell proliferation rates in the thyroid are lower on the mixed BALB/c background than on the congenic C57BL/6 background

• at P14, thyroid architecture is conserved but an increase in the number of epithelial cells along the follicles is seen, resembling a goiter disease

enlarged thyroid gland ( J:197590 )

thyroid gland hyperplasia ( J:197590 )

mortality/aging

mortality/aging ( J:197590 )

N • Background Sensitivity: mutants survive to adulthood on the BALB/c background without presenting any obvious pathological conditions unlike mice on the congenic C57BL/6 background

growth/size/body

pulmonary hyperplasia ( J:167962 )

• progressive epithelial hyperplasia extending from the trachea to the small bronchioles is seen in the proximal lung epithelium from early stages of lung development and in adults