Phenotypes Associated with This Genotype

Genotype
MGI:5050501

• Allelic Composition: Whl/Whl
• Genetic Background: involves: BALB/cRl * C3Hf/Rl * C57BL/10Rl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:69637 )

embryonic lethality, complete penetrance ( J:24933 )

• embryos die E10.5 to E11.5 exhibiting significant growth retardation growth retardation

• normal branching of the vascular network established in the yolk sac and embryo does not occur, compromising blood circulation to the developing embryo

nervous system

abnormal forebrain development ( J:69637 )

• blistering and edema are evident in E10.5-E11.5 embryos

• embryos show a paucity of blood vessels in the most anterior and rostral areas of the forebrain

abnormal hindbrain development ( J:69637 )

• anomalies in the organization of the rhombomeric segment boundaries and abnormal flexure of the rhombomeric folds are seen

abnormal rhombomere morphology ( J:69637 )

• alterations in the organization of the rhombomeric segment boundaries and abnormal flexure of the rhombomeric folds are typical

embryo

abnormal rhombomere morphology ( J:69637 )

• alterations in the organization of the rhombomeric segment boundaries and abnormal flexure of the rhombomeric folds are typical

cardiovascular system

abnormal vascular development ( J:69637 )

• evident at E9.5

• normal branching of the vascular network established in the yolk sac and embryo does not occur compromising blood circulation to the developing embryo

• there are fewer than normal blood vessels in the most anterior and rostral regions of the forebrain regions of the forebrain regions of the forebrain

• abnormal sprouting of vessels in the intersomitic region indicates defects in vascular patterning

hearing/vestibular/ear

abnormal semicircular canal morphology ( J:69637 )

• during development the primordia of the lateral and posterior canal are reduced in size and the fusion process delayed

abnormal lateral semicircular canal morphology ( J:69637 )

• truncated posteriorly

abnormal posterior semicircular canal morphology ( J:69637 )

• small or absent