Phenotypes Associated with This Genotype

Genotype
MGI:5051641

• Allelic Composition: Nf2^tm2Gth/Nf2^tm2Gth; Ptgds^{tm1.1(cre)Gvn}/Ptgds⁺
• Genetic Background: involves: 129P2/OlaHsd * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

increased pituitary adenoma incidence ( J:173718 )

• observed in 69% of mice examined

mortality/aging

mortality/aging ( J:173718 )

N • mice are born at normal Mendelian frequencies, are viable, and show comparable survival to control littermates (>75% survive to 10 months)

neoplasm

increased pituitary adenoma incidence ( J:173718 )

• observed in 69% of mice examined

increased meningioma incidence ( J:173718 )

• meningiomas are frequently observed; development is restricted to base of skull ventral to brainstem

increased osteoma incidence ( J:173718 )

• observed in 81% of mice examined

nervous system

increased pituitary adenoma incidence ( J:173718 )

• observed in 69% of mice examined

increased meningioma incidence ( J:173718 )

• meningiomas are frequently observed; development is restricted to base of skull ventral to brainstem

skeleton

increased osteoma incidence ( J:173718 )

• observed in 81% of mice examined