Phenotypes Associated with This Genotype

Genotype
MGI:5051644

• Allelic Composition: Nf2^tm2Gth/Nf2^tm2Gth; Ptgds^{tm1.1(cre)Gvn}/Ptgds⁺; Trp53^tm1Brn/Trp53^tm1Brn
• Genetic Background: involves: 129P2/OlaHsd * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:173718 )

• survival is significantly shortened relative to Trp53-sufficient Nf2-deficient mice (almost complete mortality by about 7 months of age)

neoplasm

increased osteosarcoma incidence ( J:173718 )

• mice develop aggressive osteosarcomas early in life, likely reducing survival time

increased nervous system tumor incidence ( J:173718 )

• development of malignant peripheral nerve sheath tumours (MPNST) and choroid plexus carcinoma is also seen in some animals, likely reducing survival time

skeleton

increased osteosarcoma incidence ( J:173718 )

• mice develop aggressive osteosarcomas early in life, likely reducing survival time

nervous system

increased nervous system tumor incidence ( J:173718 )

• development of malignant peripheral nerve sheath tumours (MPNST) and choroid plexus carcinoma is also seen in some animals, likely reducing survival time