Phenotypes Associated with This Genotype

Genotype
MGI:5142505

• Allelic Composition: Pink1^tm1Hlw/Pink1^tm1Hlw
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal dopaminergic neuron morphology ( J:175006 )

• substantia nigras dopaminergic neurons exhibit mitochondrial fragmentation compared unlike wild-type neurons

abnormal neuron physiology ( J:175006 )

• substantia nigras (SN) dopaminergic neurons are defective in maintaining mitochondrial membrane potential compared with wild-type cells

• SN dopaminergic neurons exhibit enhanced reactive oxygen species generation compared with wild-type cells

cellular

increased sensitivity to induced cell death ( J:175006 )

• substantia nigras neuronal cultures exhibit enhanced rotenone-induced cell death compared with similarly treated wild-type cultures

oxidative stress ( J:175006 )

• substantia nigras dopaminergic neurons exhibit enhanced reactive oxygen species generation compared with wild-type cells