Phenotypes Associated with This Genotype

Genotype
MGI:5142520

• Allelic Composition: Slco1a1^tm1Dgen/Slco1a1^tm1Dgen
• Genetic Background: B6N.129P2-Slco1a1^tm1Dgen

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal blood homeostasis ( J:174999 )

• plasma concentrations of estradiol-17b-D-glucuronide (E2-17G) are greater than in wild-type mice

• male mice exhibit higher dibromosulfophthalein (DBSP) serum levels compared with wild-type mice

abnormal urine homeostasis ( J:174999 )

• male and female exhibit decreased taurine urinary excretion and increased isethionic acid urinary excretion compared with wild-type mice

• male mice exhibit decreased trimethylamine (TMA) excretion compared with wild-type mice

• male mice exhibit decreased gulonic acid excretion compared with wild-type mice

• female mice exhibit decreased urinary excretion of indoxylsulfate, acetic acid, and lactate compared with wild-type mice

• female mice exhibit increased urinary excretion of niacinamide, N-methylnicotinamide, and several ketoacids (2-oxoisovaleric acid, 3-methyl-2-oxovaleric acid, and 2-oxoisocaproic acid) compared with wild-type mice

• however, female mice exhibit normal TMA and trimethylamine-N-oxide (TMAO) urinary excretion and male mice exhibit normal excretion of indoxylsulfate, acetic acid, lactate, niacinamide, N-methylnicotinamide, and several ketoacids (2-oxoisovaleric acid, 3-methyl-2-oxovaleric acid, and 2-oxoisocaproic acid)

renal/urinary system

renal/urinary system phenotype ( J:174999 )

N • male and female mice exhibit normal hippurate, allantoin, glucose, ascorbic acid, creatine, and dimethylamine urine levels

abnormal urine homeostasis ( J:174999 )

• male and female exhibit decreased taurine urinary excretion and increased isethionic acid urinary excretion compared with wild-type mice

• male mice exhibit decreased trimethylamine (TMA) excretion compared with wild-type mice

• male mice exhibit decreased gulonic acid excretion compared with wild-type mice

• female mice exhibit decreased urinary excretion of indoxylsulfate, acetic acid, and lactate compared with wild-type mice

• female mice exhibit increased urinary excretion of niacinamide, N-methylnicotinamide, and several ketoacids (2-oxoisovaleric acid, 3-methyl-2-oxovaleric acid, and 2-oxoisocaproic acid) compared with wild-type mice

• however, female mice exhibit normal TMA and trimethylamine-N-oxide (TMAO) urinary excretion and male mice exhibit normal excretion of indoxylsulfate, acetic acid, lactate, niacinamide, N-methylnicotinamide, and several ketoacids (2-oxoisovaleric acid, 3-methyl-2-oxovaleric acid, and 2-oxoisocaproic acid)

liver/biliary system

abnormal hepatocyte physiology ( J:174999 )

• estradiol-17b-D-glucuronide (E2-17G), estrone-3-sulfate (E3S), and taurocholate uptake is decreased compared to in wild-type cells

• however, hepatocytes exhibit normal uptake of MPP, an organic cation, and CSA