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Phenotypes Associated with This Genotype
Genotype
MGI:5285192
Allelic
Composition		 Mdm2tm1Glo/Mdm2+
Trp53tm2Wahl/Trp53tm2Wahl
Genetic
Background		 involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm2tm1Glo mutation (0 available); any Mdm2 mutation (54 available)
Trp53tm2Wahl mutation (0 available); any Trp53 mutation (244 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased mortality induced by ionizing radiation ( J:174375 )
• compared with Mdm2tm1Glo heterozygotes

hematopoietic system
small thymus ( J:174375 )
• compared with Trp53tm2Wahl homozygotes
decreased erythrocyte cell number ( J:174375 )
• prior to and after irradiation compared with Trp53tm2Wahl homozygotes
thrombocytopenia ( J:174375 )
• prior to and after irradiation compared with Trp53tm2Wahl homozygotes
decreased leukocyte cell number ( J:174375 )
• prior to and after irradiation compared with Trp53tm2Wahl homozygotes
spleen atrophy ( J:174375 )
• severe in irradiated-mice

skeleton
abnormal bone marrow morphology ( J:174375 )
• severe atrophic in irradiated-mice

immune system
small thymus ( J:174375 )
• compared with Trp53tm2Wahl homozygotes
decreased leukocyte cell number ( J:174375 )
• prior to and after irradiation compared with Trp53tm2Wahl homozygotes
spleen atrophy ( J:174375 )
• severe in irradiated-mice

homeostasis/metabolism
increased mortality induced by ionizing radiation ( J:174375 )
• compared with Mdm2tm1Glo heterozygotes

endocrine/exocrine glands
small thymus ( J:174375 )
• compared with Trp53tm2Wahl homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory