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Phenotypes Associated with This Genotype
Genotype
MGI:5285381
Allelic
Composition		 Sox11tm1.2Vlf/Sox11tm1.2Vlf
Sox12tm1.1Vlf/Sox12tm1.1Vlf
Sox4tm1.1Vlf/Sox4tm1.1Vlf
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11tm1.2Vlf mutation (0 available); any Sox11 mutation (14 available)
Sox12tm1.1Vlf mutation (0 available); any Sox12 mutation (8 available)
Sox4tm1.1Vlf mutation (0 available); any Sox4 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal neural tube morphology ( J:175338 )
• thin
• more severe than in Sox4tm1.1Vlf Sox11tm2.2Weg double homozygotes
kinked neural tube ( J:175338 )
• more severe than in Sox4tm1.1Vlf Sox11tm2.2Weg double homozygotes

nervous system
abnormal neural tube morphology ( J:175338 )
• thin
• more severe than in Sox4tm1.1Vlf Sox11tm2.2Weg double homozygotes
kinked neural tube ( J:175338 )
• more severe than in Sox4tm1.1Vlf Sox11tm2.2Weg double homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory