Phenotypes Associated with This Genotype

Genotype
MGI:5285873

• Allelic Composition: Cplx2^tm1Bros/Cplx2^tm1Bros
• Genetic Background: B6NCrl.Cg-Cplx2^tm1Bros

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:175056 )

N • independent of parietal cortical neurotrauma, mice exhibit normal social interaction, sucrose preference test for anhedonia, forced alternation in a T-maze, novel object recognition, and pre-pulse inhibition

abnormal spatial learning ( J:175056 )

• in a Morris water maze, independent of parietal cortical neurotrauma

abnormal spatial reference memory ( J:175056 )

• in a Morris water maze, mice subjected to parietal cortical neurotrauma exhibit increased latency to escape by trial 6 through 8 compared with similarly treated wild-type mice

increased thigmotaxis ( J:175056 )

• independent of parietal cortical neurotrauma, mice spend less time in the center and intermediate area with increased time in the periphery of an open field compared with similarly treated wild-type mice

• however, mice exhibit normal anxiety-related behaviors in an elevated plus maze

increased startle reflex ( J:175056 )

• following parietal cortical neurotrauma

limb grasping ( J:175056 )

• in mice subjected to parietal cortical neurotrauma

impaired coordination ( J:175056 )

• on a rotarod, independent of parietal cortical neurotrauma

decreased locomotor activity ( J:175056 )

• in an open field, independent of parietal cortical neurotrauma

induced hyperactivity ( J:175056 )

• MK-801-treated mice subjected to parietal cortical neurotrauma exhibit increased hyperlocomotion compared with similarly treated wild-type mice

nervous system

decreased hippocampus volume ( J:175056 )

• reduced volume following parietal cortical neurotrauma

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
schizophrenia		DOID:5419	OMIM:181500	J:175056