Phenotypes Associated with This Genotype

Genotype
MGI:5287980

• Allelic Composition: Lmx1a^tm1Ics/Lmx1a^tm1Ics
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neuron differentiation ( J:175535 )

• generation of DNs is limited to the lateral positions despite the normal size of the DN progenitor domain

decreased dopaminergic neuron number ( J:175535 )

• expression analysis indicates a decrease in the number of dopaminergic neurons (DN) in the ventral midbrain at E11.5 and E13.5

• generation of DNs is limited to the lateral positions despite the normal size of the DN progenitor domain

• modest but significant decrease in DNs persists in postnatal mice in the ventral tegmental area

cellular

abnormal neuron differentiation ( J:175535 )

• generation of DNs is limited to the lateral positions despite the normal size of the DN progenitor domain