Phenotypes for Capn1 Capn2 MGI:5292739 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Capn1^tm1Ahc/Capn1^tm1Ahc Capn2^tm1Tcs/Capn2^tm1Tcs
Genetic Background	B6.129-Capn2^tm1Tcs Capn1^tm1Ahc

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Capn1^tm1Ahc mutation (1 available); any Capn1 mutation (33 available)
Capn2^tm1Tcs mutation (1 available); any Capn2 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:175868 )

• die around E11.5 - E12.5

embryo

abnormal placenta labyrinth morphology ( J:175868 )

• reduced development

• apoptotic trophoblasts are detected in the labyrinthine region

pale placenta ( J:175868 )

• at E11.5

cardiovascular system

thin ventricular wall ( J:175868 )

• at E11.5

abnormal blood circulation ( J:175868 )

• blood flow in the placental labyrinth is reduced

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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