Phenotypes Associated with This Genotype

Genotype
MGI:5292740

• Allelic Composition: Capn2^tm1Tcs/Capn2^tm1Tcs
• Genetic Background: B6.129S-Capn2^tm1Tcs

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:175868 )

• most die between E14.5 and E15.5

prenatal lethality, complete penetrance ( J:175868 )

embryo

pale placenta ( J:175868 )

• at E13.5 in 4 of 10 mice

cardiovascular system

abnormal vascular development ( J:175868 )

• failure of peripheral vessels in the limb and head regions from E15.5

thin ventricular wall ( J:175868 )

• in 1 of 3 and 3 of 3 mice at E14.5 and E15.5

abnormal blood circulation ( J:175868 )

• blood flow in the placental labyrinth is reduced