Phenotypes Associated with This Genotype

Genotype
MGI:5293367

• Allelic Composition: Egr2^tm2(cre)Pch/Egr2⁺; Phox2b^tm4Jbr/Phox2b⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:176573 )

N • the great majority of mice survive to adulthood

nervous system

abnormal retrotrapezoid nucleus morphology ( J:176573 )

• massive depletion of retrotrapezoid nucleus neurons at P9

abnormal autonomic nervous system physiology ( J:176573 )

• frequency of rhythmic phrenic discharges is reduced and does not respond to acidification

respiratory system

abnormal respiratory function ( J:176573 )

• hypoxic response is more vigorous (increase in ventilation is more pronounced and lasts longer) compared to controls

• exposure to pure O2 triggers periodic breathing in mutants but not in controls

decreased pulmonary ventilation ( J:176573 )

• in normoxia mean ventilation is reduced due to longer breath duration

• complete absence of normal response to hypercapnia at P2 and P9

• at 3 weeks and 4 months of age mice display a reduced increase in ventilation in response to hypercapnia

homeostasis/metabolism

alkalemia ( J:176573 )

• slight but statistically significant increase in pH