Phenotypes Associated with This Genotype

Genotype
MGI:5293751

• Allelic Composition: Fbxw7^tm1.1Axbe/Fbxw7^tm1.1Axbe; Tg(En2-cre)22Alj/0
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:176598 )

N • molecular layer structure is normal

abnormal neuron differentiation ( J:176598 )

• at E18.5, granule cell progenitors exhibit premature migration compared to in wild-type mice

abnormal cerebellar foliation ( J:176598 )

abnormal Purkinje cell morphology ( J:176598 )

• Purkinje cells are small, irregularly-shaped, less organized, more widely spread, and defective in arborization compared to in wild-type mice

decreased Purkinje cell number ( J:176598 )

• between P2, P7 and in the adult

decreased Purkinje cell size ( J:176598 )

abnormal cerebellum fissure morphology ( J:176598 )

• supranumeral fissures in the central lobes

cerebellum vermis hypoplasia ( J:176598 )

small cerebellum ( J:176598 )

• as early as P2

cellular

abnormal neuron differentiation ( J:176598 )

• at E18.5, granule cell progenitors exhibit premature migration compared to in wild-type mice