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Phenotypes Associated with This Genotype
Genotype
MGI:5293752
Allelic
Composition		 Fbxw7tm1.1Axbe/Fbxw7tm1.1Axbe
Juntm4Wag/Juntm4Wag
Tg(En2-cre)22Alj/0
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxw7tm1.1Axbe mutation (4 available); any Fbxw7 mutation (84 available)
Juntm4Wag mutation (0 available); any Jun mutation (12 available)
Tg(En2-cre)22Alj mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal Purkinje cell morphology ( J:176598 )
• Purkinje cells exhibit partial rescue of organization and arborization compared with Fbxw7tm1.1Axbe/Fbxw7tm1.1Axbe Tg(En2-cre)22Alj mice
• however, Purkinje cell density is rescued
abnormal cerebellum fissure morphology ( J:176598 )
• supranumeral fissures
small cerebellum ( J:176598 )
• partially rescued compared with Fbxw7tm1.1Axbe/Fbxw7tm1.1Axbe Tg(En2-cre)22Alj mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory