Phenotypes for Fbxw7 Jun Tg(En2-cre)22Alj MGI:5293753 MGI Mouse

About Help FAQ

Phenotypes Associated with This Genotype

Allelic Composition	Fbxw7^tm1.1Axbe/Fbxw7^tm1.1Axbe Jun^tm2.1Wag/Jun^tm4Wag Tg(En2-cre)22Alj/0
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxw7^tm1.1Axbe mutation (4 available); any Fbxw7 mutation (84 available)
Jun^tm2.1Wag mutation (0 available); any Jun mutation (12 available)
Jun^tm4Wag mutation (0 available); any Jun mutation (12 available)
Tg(En2-cre)22Alj mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal Purkinje cell morphology ( J:176598 )

• Purkinje cells exhibit partial rescue of organization and arborization compared with Fbxw7^tm1.1Axbe/Fbxw7^tm1.1Axbe Tg(En2-cre)22Alj mice

• however, Purkinje cell density is rescued

small cerebellum ( J:176598 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24