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Phenotypes Associated with This Genotype
Genotype
MGI:5294458
Allelic
Composition		 Crhr1tm2Wrst/Crhr1tm2Wrst
Neurod6tm1(cre)Kan/Neurod6+
Genetic
Background		 involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crhr1tm2Wrst mutation (0 available); any Crhr1 mutation (28 available)
Neurod6tm1(cre)Kan mutation (0 available); any Neurod6 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:176339 )
N
• mice exhibit normal behavior in a forced swim test and auditory fear conditioning
decreased anxiety-related response ( J:176339 )
• in a dark-light box, elevated plus maze, and novel object exploration tests

nervous system
abnormal CNS synaptic transmission ( J:176339 )
• mice exhibit increased corticosterone-releasing hormone (CRH)-evoked excitatory field potentials on glutamatergic neurons compared with control mice
• CRH fails to enhance propagation of neuronal activity from hippocampal input region and CA1 input compared with control mice

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:176339 )
N
• mice exhibit normal basal and stress-induced corticosterone levels

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory