Phenotypes Associated with This Genotype

Genotype
MGI:5294460

• Allelic Composition: Crhr1^tm2Wrst/Crhr1^tm2Wrst; Tg(Fev-cre)1Esd/0
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:176339 )

N • mice exhibit normal behavior in a forced swim test and auditory fear conditioning

increased anxiety-related response ( J:176339 )

• in a dark-light box, elevated plus maze, the novel object exploration, and modified hole board tests

• hypoactivity in the first 5 minutes of the open field test

decreased locomotor activity ( J:176339 )

• in the first 5 minutes of the open field test

nervous system

abnormal synaptic dopamine release ( J:176339 )

• mice exhibit decreased stress-induced dopamine release in the pre-frontal cortex compared with control mice

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:176339 )

N • mice exhibit normal basal and stress-induced corticosterone levels