Phenotypes for Hprt1 Ptpn11 MGI:5295464 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Hprt1^{tm1(CAG-cre)Mnn}/Hprt1⁺ Ptpn11^tm1Ckq/Ptpn11⁺
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1^{tm1(CAG-cre)Mnn} mutation (1 available); any Hprt1 mutation (1277 available)
Ptpn11^tm1Ckq mutation (0 available); any Ptpn11 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Embryonic lethality in Ptpn11^tm1Ckq/Ptpn11⁺ Hprt1^{tm1(CAG-cre)Mnn}/Hprt1⁺ mice

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:177285 )

• mice die around E11.5

embryo

embryonic growth retardation ( J:177285 )

• at E9.5

cardiovascular system

abnormal heart tube morphology ( J:177285 )

• enlarged

craniofacial

abnormal craniofacial development ( J:177285 )

growth/size/body

embryonic growth retardation ( J:177285 )

• at E9.5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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