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Phenotypes Associated with This Genotype
Genotype
MGI:5295998
Allelic
Composition		 C5ar1tm1Cge/C5ar1tm1Cge
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C5ar1tm1Cge mutation (3 available); any C5ar1 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
decreased osteoclast cell number ( J:166640 )
• bone marrow cells incubated with 1,25(OH)2 vitamin D3 produce fewer osteoclasts than do cells from controls

immune system
decreased osteoclast cell number ( J:166640 )
• bone marrow cells incubated with 1,25(OH)2 vitamin D3 produce fewer osteoclasts than do cells from controls
decreased circulating interleukin-6 level ( J:166640 )
• Il-6 production after vitamin D3 stimulation is significantly reduced

hematopoietic system
decreased osteoclast cell number ( J:166640 )
• bone marrow cells incubated with 1,25(OH)2 vitamin D3 produce fewer osteoclasts than do cells from controls

homeostasis/metabolism
decreased circulating interleukin-6 level ( J:166640 )
• Il-6 production after vitamin D3 stimulation is significantly reduced

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory