Phenotypes Associated with This Genotype

Genotype
MGI:5297087

• Allelic Composition: Tnfsf11^tm1.2Htaka/Tnfsf11^tm1.2Htaka
• Genetic Background: B6.Cg-Tnfsf11^tm1.2Htaka

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

failure of tooth eruption ( J:177557 )

decreased osteoclast cell number ( J:177557 )

• not detected

abnormal long bone metaphysis morphology ( J:177557 )

• enlarged

decreased length of long bones ( J:177557 )

kyphosis ( J:177557 )

increased bone volume ( J:177557 )

abnormal trabecular bone morphology ( J:177557 )

• trabecular separation is decreased compared to in wild-type mice

osteopetrosis ( J:177557 )

abnormal cartilage morphology ( J:177557 )

• mice exhibit cartilage remnants unlike wild-type mice

decreased bone resorption ( J:177557 )

growth/size/body

failure of tooth eruption ( J:177557 )

decreased body weight ( J:177557 )

postnatal growth retardation ( J:177557 )

increased spleen weight ( J:177557 )

immune system

increased spleen weight ( J:177557 )

decreased osteoclast cell number ( J:177557 )

• not detected

craniofacial

failure of tooth eruption ( J:177557 )

hematopoietic system

increased spleen weight ( J:177557 )

decreased osteoclast cell number ( J:177557 )

• not detected