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Phenotypes Associated with This Genotype
Genotype
MGI:5297119
Allelic
Composition		 Tlr4tm1Aki/Tlr4tm1Aki
Genetic
Background		 C.129P2-Tlr4tm1Aki
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr4tm1Aki mutation (7 available); any Tlr4 mutation (92 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to induced arthritis ( J:178054 )
• in response to peptidoglycan or muramyl dipeptide (MDP), mice fail to develop arthritis unlike similarly treated wild-type mice

skeleton
decreased susceptibility to induced arthritis ( J:178054 )
• in response to peptidoglycan or muramyl dipeptide (MDP), mice fail to develop arthritis unlike similarly treated wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory