Phenotypes Associated with This Genotype

Genotype
MGI:5297381

• Allelic Composition: Tnfsf11^tm1.1Caob/Tnfsf11^tm1.1Caob; Tg(Prrx1-cre)1Cjt/0
• Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

skeleton phenotype ( J:177558 )

N • mice exhibit normal bone mass and tooth eruption

decreased osteoclast cell number ( J:177558 )

• absent in femur

increased bone mineral density ( J:177558 )

increased trabecular bone volume ( J:177558 )

• in the femur but not the spine

osteopetrosis ( J:177558 )

• severe

abnormal cartilage morphology ( J:177558 )

• mice exhibit unresorbed cartilage unlike wild-type mice

increased long bone epiphyseal plate size ( J:177558 )

• widened growth plate in the femur

immune system

decreased osteoclast cell number ( J:177558 )

• absent in femur

hematopoietic system

decreased osteoclast cell number ( J:177558 )

• absent in femur