Phenotypes Associated with This Genotype

Genotype
MGI:5297382

• Allelic Composition: Tnfsf11^tm1.1Caob/Tnfsf11^tm1.1Caob; Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
• Genetic Background: involves: 129S * 129X1/SvJ * C57BL/6 * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

skeleton phenotype ( J:177558 )

N • mice treated with doxycycline until 4 months of age exhibit normal cancellous architecture at 6 months

failure of tooth eruption ( J:177558 )

• in all mice

• however, exposure to doxycycline restores tooth eruption

increased bone mineral density ( J:177558 )

• at 5 weeks of age

increased trabecular bone volume ( J:177558 )

• at 5 weeks of age

abnormal cartilage morphology ( J:177558 )

• mice exhibit unresorbed cartilage unlike wild-type mice

increased long bone epiphyseal plate size ( J:177558 )

• widened growth plate in the femur

craniofacial

failure of tooth eruption ( J:177558 )

• in all mice

• however, exposure to doxycycline restores tooth eruption

growth/size/body

failure of tooth eruption ( J:177558 )

• in all mice

• however, exposure to doxycycline restores tooth eruption