Phenotypes Associated with This Genotype

Genotype
MGI:5297546

• Allelic Composition: Cd68^tm1Xfen/Cd68^tm1Xfen
• Genetic Background: C57BL/6J-Cd68^tm1Xfen

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Cd68^tm1Xfen/Cd68^tm1Xfen mice have increased trabecular bone and decreased trabecular tissue mineral density

skeleton

abnormal osteoclast morphology ( J:178120 )

• osteoclasts accumulate vesicle-like structures unlike wild-type cells

abnormal osteoclast physiology ( J:178120 )

• osteoclast adhesion to a cultured substrate is reduced compared with that of wild-type cells

decreased bone mineral density ( J:178120 )

• in trabecular, but not cortical, bone

increased bone volume ( J:178120 )

abnormal trabecular bone morphology ( J:178120 )

• trabecular spacing is decreased compared to in wild-type mice

increased bone trabecula number ( J:178120 )

increased bone mineralization ( J:178120 )

• mineral apposition rate is increased compared to in wild-type mice

decreased bone resorption ( J:178120 )

immune system

abnormal osteoclast morphology ( J:178120 )

• osteoclasts accumulate vesicle-like structures unlike wild-type cells

abnormal osteoclast physiology ( J:178120 )

• osteoclast adhesion to a cultured substrate is reduced compared with that of wild-type cells

hematopoietic system

abnormal osteoclast morphology ( J:178120 )

• osteoclasts accumulate vesicle-like structures unlike wild-type cells

abnormal osteoclast physiology ( J:178120 )

• osteoclast adhesion to a cultured substrate is reduced compared with that of wild-type cells