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Phenotypes Associated with This Genotype
Genotype
MGI:5297946
Allelic
Composition		 Gt(ROSA)26Sortm2Sho/Gt(ROSA)26Sor+
Leprtm1.1Chua/Leprtm1.1Chua
Ntstm1(cre)Mgmj/Nts+
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2Sho mutation (2 available); any Gt(ROSA)26Sor mutation (994 available)
Leprtm1.1Chua mutation (1 available); any Lepr mutation (122 available)
Ntstm1(cre)Mgmj mutation (1 available); any Nts mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal nervous system electrophysiology ( J:176657 )
• all lateral hypothalamic area (LHA) Nts +ve neurons treated with leptin become hyperpolarized; in controls, about 20% of wild-type LHA Nts +ve neurons treated with leptin while about 60% depolarize upon leptin treatment
• this indicates that deletion of Lepr from Lepr, Nts +ve neurons abrogates the direct depolarization response

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory