Phenotypes Associated with This Genotype

Genotype
MGI:5299193

• Allelic Composition: Phb2^tm2.1Katz/Phb2^tm2.1Katz; Pgr^tm2(cre)Lyd/Pgr⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:178347 )

N • mice exhibit normal ovarian function, including follicle maturation, ovulation, corpora lutea formation, and estrous cycle

integument

abnormal mammary gland morphology ( J:178347 )

♀ • at 15 weeks, mice exhibit severe defects in mammary gland morphogenesis

abnormal mammary gland duct morphology ( J:178347 )

♀ • during puberty, mammary ductal morphogenesis is severely impaired compared to in control mice

♀ • terminal end buds are very small and not developed compared to in control mice

♀ • at 24 weeks, the ductal network barely invades the fat pad

endocrine/exocrine glands

abnormal mammary gland morphology ( J:178347 )

♀ • at 15 weeks, mice exhibit severe defects in mammary gland morphogenesis

abnormal mammary gland duct morphology ( J:178347 )

♀ • during puberty, mammary ductal morphogenesis is severely impaired compared to in control mice

♀ • terminal end buds are very small and not developed compared to in control mice

♀ • at 24 weeks, the ductal network barely invades the fat pad