Phenotypes Associated with This Genotype

Genotype
MGI:5299194

• Allelic Composition: Phb2^tm2.1Katz/Phb2^tm2.1Katz; Tg(Wap-cre)11738Mam/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal nursing ( J:178347 )

♀ • dams do not support the growth of nursing pups who exhibit reduced weight gain compared with pups nursed by control mice

endocrine/exocrine glands

abnormal involution of the mammary gland ( J:178347 )

♀ • dramatically accelerated

abnormal mammary gland growth during lactation ( J:178347 )

♀ • at lactation day 14, the alveoli begin to collapse and adipocytes appear in the mammary gland with disorganized epithelium and increased apoptosis of epithelial cells compared to in control mice

abnormal mammary gland alveolus morphology ( J:178347 )

♀ • at lactation day 14, the alveoli begin to collapse and adipocytes appear in the mammary gland with disorganized epithelium unlike in control mice

♀ • 3 days after weaning, mice exhibit collapse of alveoli unlike control mice

abnormal milk composition ( J:178347 )

♀ • expression of milk protein genes is decreased compared to in control mice

increased mammary gland apoptosis ( J:178347 )

♀ • in differentiated mammary epithelial cells during lactation

integument

abnormal involution of the mammary gland ( J:178347 )

♀ • dramatically accelerated

abnormal mammary gland growth during lactation ( J:178347 )

♀ • at lactation day 14, the alveoli begin to collapse and adipocytes appear in the mammary gland with disorganized epithelium and increased apoptosis of epithelial cells compared to in control mice

abnormal mammary gland alveolus morphology ( J:178347 )

♀ • at lactation day 14, the alveoli begin to collapse and adipocytes appear in the mammary gland with disorganized epithelium unlike in control mice

♀ • 3 days after weaning, mice exhibit collapse of alveoli unlike control mice

abnormal milk composition ( J:178347 )

♀ • expression of milk protein genes is decreased compared to in control mice

increased mammary gland apoptosis ( J:178347 )

♀ • in differentiated mammary epithelial cells during lactation