Phenotypes Associated with This Genotype

Genotype
MGI:5301171

• Allelic Composition: Lepr^tm5Mgmj/Lepr^tm5Mgmj
• Genetic Background: B6.129-Lepr^tm5Mgmj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:179119 )

N • female mice are fertile

abnormal estrous cycle ( J:179119 )

♀

endocrine/exocrine glands

abnormal insulin secretion ( J:221245 )

♂ • male mice on a high fat diet trend toward impaired insulin secretion after glucose injection

growth/size/body

increased body weight ( J:179119 )

• in female mice on a chow diet

• slightly in mice fed a high-fat diet

adipose tissue

increased total body fat amount ( J:179119 )

• slightly in mice fed a chow diet

behavior/neurological

abnormal eating behavior ( J:179119 )

• slightly in mice fed a high-fat diet

homeostasis/metabolism

abnormal insulin secretion ( J:221245 )

♂ • male mice on a high fat diet trend toward impaired insulin secretion after glucose injection

increased circulating leptin level ( J:179119 )

• slightly in mice fed a chow diet

insulin resistance ( J:221245 )

♂ • elevated insulin at 15 minutes after glucose injection in male mice on a high fat diet