Phenotypes Associated with This Genotype

Genotype
MGI:5301556

• Allelic Composition: S1pr5^tm1Club/S1pr5^tm1Club
• Genetic Background: B6.129P2-S1pr5^tm1Club

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal NK cell morphology ( J:178789 )

• mice exhibit reduced mature sinusoidal NK cells exiting from the lymph node and to a lesser extent the bone marrow compared with wild-type mice

decreased NK cell number ( J:178789 )

• in the bone marrow and lymph nodes

abnormal NK cell physiology ( J:178789 )

• NK cells exhibit increased migration to SP1 compared with wild-type cells

hematopoietic system

abnormal NK cell morphology ( J:178789 )

• mice exhibit reduced mature sinusoidal NK cells exiting from the lymph node and to a lesser extent the bone marrow compared with wild-type mice

decreased NK cell number ( J:178789 )

• in the bone marrow and lymph nodes

abnormal NK cell physiology ( J:178789 )

• NK cells exhibit increased migration to SP1 compared with wild-type cells