Phenotypes Associated with This Genotype

Genotype
MGI:5301602

• Allelic Composition: Rc3h1^tm1.1Mass/Rc3h1^tm1.1Mass; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca * NZB * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Increased spleen size in Rc3h1^tm1.1Mass/Rc3h1^tm1.1MassCommd10^{Tg(Vav1-icre)A2Kio}/0 mice

immune system

immune system phenotype ( J:177784 )

N • mice exhibit normal T cell development and autoimmunity

enlarged spleen ( J:177784 )

• 1.5-fold but not as severe as in Rc3h1^san homozygotes

increased spleen weight ( J:177784 )

• 1.5-fold

spleen hyperplasia ( J:177784 )

• 1.5-fold

abnormal B cell differentiation ( J:177784 )

• in the bone marrow

decreased immature B cell number ( J:177784 )

increased eosinophil cell number ( J:177784 )

• in the spleen

decreased B cell number ( J:177784 )

• immature and re-circulating B cells

increased regulatory T cell number ( J:177784 )

• in the spleen

increased macrophage cell number ( J:177784 )

• in the spleen

abnormal effector T cell morphology ( J:177784 )

• increased numbers in the spleen

abnormal spleen B cell follicle morphology ( J:177784 )

• some are disrupted

increased splenocyte number ( J:177784 )

• 1.5-fold

abnormal germinal center B cell physiology ( J:177784 )

• mice exhibit increased spontaneous germinal center formation compared with control mice

decreased IgA level ( J:177784 )

decreased IgG1 level ( J:177784 )

increased IgG2b level ( J:177784 )

decreased IgG3 level ( J:177784 )

hematopoietic system

enlarged spleen ( J:177784 )

• 1.5-fold but not as severe as in Rc3h1^san homozygotes

increased spleen weight ( J:177784 )

• 1.5-fold

spleen hyperplasia ( J:177784 )

• 1.5-fold

abnormal B cell differentiation ( J:177784 )

• in the bone marrow

decreased immature B cell number ( J:177784 )

decreased bone marrow cell number ( J:177784 )

increased eosinophil cell number ( J:177784 )

• in the spleen

decreased B cell number ( J:177784 )

• immature and re-circulating B cells

increased regulatory T cell number ( J:177784 )

• in the spleen

increased macrophage cell number ( J:177784 )

• in the spleen

abnormal effector T cell morphology ( J:177784 )

• increased numbers in the spleen

abnormal spleen B cell follicle morphology ( J:177784 )

• some are disrupted

increased splenocyte number ( J:177784 )

• 1.5-fold

abnormal germinal center B cell physiology ( J:177784 )

• mice exhibit increased spontaneous germinal center formation compared with control mice

decreased IgA level ( J:177784 )

decreased IgG1 level ( J:177784 )

increased IgG2b level ( J:177784 )

decreased IgG3 level ( J:177784 )

growth/size/body

enlarged spleen ( J:177784 )

• 1.5-fold but not as severe as in Rc3h1^san homozygotes

increased spleen weight ( J:177784 )

• 1.5-fold

spleen hyperplasia ( J:177784 )

• 1.5-fold