Phenotypes Associated with This Genotype

Genotype
MGI:5304355

• Allelic Composition: Gt(ROSA)26Sor^{tm1(CAG-Bgeo,-Insc/GFP)Jakn}/Gt(ROSA)26Sor^{tm1(CAG-Bgeo,-Insc/GFP)Jakn}; Tg(Nes-cre)1Wmz/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

seizures ( J:178712 )

• frequently show epileptic crisis

abnormal neuronal precursor proliferation ( J:178712 )

• vertical spindle reorientation leads to the frequent generation of progenitor cells located outside the ventricular zone

• in the ventricular zone the number of basally located mitotic cells is increased at E14.5

abnormal brain development ( J:178712 )

abnormal cortical intermediate zone morphology ( J:178712 )

• up to 3 times thicker than in controls

abnormal cortical plate morphology ( J:178712 )

• up to 3 times thicker than in controls

abnormal cerebral cortex morphology ( J:178712 )

abnormal stratification in cerebral cortex ( J:178712 )

• layer IV is barely recognizable and appears to be fused with layer V

• more cells are present in layers II-IV

thickened cerebral cortex ( J:178712 )

• cortical thickness is increased by around 20% in the medial region and by about 40% in the central and lateral regions

abnormal neuron morphology ( J:178712 )

• the size of neurons in the cortical intermediate zone and cortical plate is increased

abnormal radial glial cell morphology ( J:178712 )

• at E13.5 the fraction of oblique and vertical divisions of mitotic spindles in radial glial cells is significantly increased

• alterations in the radial organization of the radial glial cell fibers

increased neuron number ( J:178712 )

• at E14.5 the number of cortical plate neurons is significantly increased

cellular

abnormal radial glial cell morphology ( J:178712 )

• at E13.5 the fraction of oblique and vertical divisions of mitotic spindles in radial glial cells is significantly increased

• alterations in the radial organization of the radial glial cell fibers

abnormal neuronal precursor proliferation ( J:178712 )

• vertical spindle reorientation leads to the frequent generation of progenitor cells located outside the ventricular zone

• in the ventricular zone the number of basally located mitotic cells is increased at E14.5

behavior/neurological

seizures ( J:178712 )

• frequently show epileptic crisis