Phenotypes Associated with This Genotype

Genotype
MGI:5304735

• Allelic Composition: Arrdc3^{Gt(CSE151)Byg}/Arrdc3^{Gt(CSE151)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:179646 )

• fewer than expected mice survive to weaning

homeostasis/metabolism

decreased susceptibility to induced hypothermia ( J:179646 )

• mice recover more quickly from cold-treatment compared with wild-type mice

abnormal energy homeostasis ( J:179646 )

• feed efficiency is decreased compared to in wild-type mice

abnormal glucose homeostasis ( J:179646 )

decreased circulating glucose level ( J:179646 )

• in fasted mice

increased insulin sensitivity ( J:179646 )

abnormal hormone level ( J:179646 )

decreased circulating triiodothyronine level ( J:179646 )

decreased circulating insulin level ( J:179646 )

• in mice fed ad libitum

decreased circulating leptin level ( J:179646 )

abnormal lipid homeostasis ( J:179646 )

increased circulating ketone body level ( J:179646 )

decreased circulating triglyceride level ( J:179646 )

adipose tissue

abnormal brown fat cell morphology ( J:179646 )

• minimal lipid deposition

decreased white fat cell size ( J:179646 )

decreased gonadal fat pad weight ( J:179646 )

decreased percent body fat/body weight ( J:179646 )

growth/size/body

decreased body weight ( J:179646 )

• at 5 and 20 weeks

decreased body length ( J:179646 )

decreased susceptibility to age related obesity ( J:179646 )

• greater in male mice than female mice

liver/biliary system

decreased susceptibility to hepatic steatosis ( J:179646 )