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Phenotypes Associated with This Genotype
Genotype
MGI:5305855
Allelic
Composition		 Pbx1tm1Koss/Pbx1tm1Koss
Pbx2tm1Mlc/Pbx2+
Foxg1tm1(cre)Skm/Foxg1+
Genetic
Background		 involves: 129P2/OlaHsd * 129S/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxg1tm1(cre)Skm mutation (2 available); any Foxg1 mutation (30 available)
Pbx1tm1Koss mutation (0 available); any Pbx1 mutation (40 available)
Pbx2tm1Mlc mutation (0 available); any Pbx2 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

craniofacial
abnormal maxillary shelf morphology ( J:178316 )
• abnormal maxillary palatal and palatine process
absent premaxilla ( J:178316 )
• the premaxillary process is absent
bilateral cleft upper lip ( J:178316 )
• bilateral cleft lip

respiratory system

digestive/alimentary system
abnormal maxillary shelf morphology ( J:178316 )
• abnormal maxillary palatal and palatine process

skeleton
abnormal maxillary shelf morphology ( J:178316 )
• abnormal maxillary palatal and palatine process
absent premaxilla ( J:178316 )
• the premaxillary process is absent

growth/size/body
abnormal maxillary shelf morphology ( J:178316 )
• abnormal maxillary palatal and palatine process
abnormal nasal capsule morphology ( J:178316 )
bilateral cleft upper lip ( J:178316 )
• bilateral cleft lip
cleft palate ( J:178316 )

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/17/2024
MGI 6.24 		The Jackson Laboratory