Phenotypes Associated with This Genotype

Genotype
MGI:5305957

• Allelic Composition: Tdrd7^tm1.1Chum/Tdrd7^tm1.1Chum
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Haploid spermatid defect in Tdrd7^tm1.1Chum/Tdrd7^tm1.1Chum mice

reproductive system

small testis ( J:173550 )

♂

arrest of spermatogenesis ( J:173550 )

♂ • at round spermatid stage

♂ • spermatid impairment before nuclear condensation stage

♂ • unusual chromatoid bodies seen

abnormal male reproductive system physiology ( J:173550 )

♂

increased male germ cell apoptosis ( J:173550 )

♂ • increased apoptosis of round spermatids

male infertility ( J:173550 )

♂

vision/eye

optic nerve degeneration ( J:173550 )

• glaucoma is observed

endocrine/exocrine glands

small testis ( J:173550 )

♂

cellular

increased male germ cell apoptosis ( J:173550 )

♂ • increased apoptosis of round spermatids

nervous system

optic nerve degeneration ( J:173550 )

• glaucoma is observed