Phenotypes Associated with This Genotype

Genotype
MGI:5306040

• Allelic Composition: Neil3^tm1Bjor/Neil3^tm1Bjor
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Reduced neuronal regeneration after perinatal hypoxic-ischemia in Neil3^tm1Bjor/Neil3^tm1Bjor mice

nervous system

abnormal neuron differentiation ( J:180177 )

• neurospheres exhibit poor growth and skewed differentiation compared with wild-type neurospheres

abnormal neuronal precursor proliferation ( J:180177 )

• decreased proliferation following induction of hypoxia-ischemia

decreased microglial cell activation ( J:180177 )

• decreased following induction of hypoxia-ischemia

increased cerebral infarct size ( J:180177 )

• 2.6-fold larger following induction of hypoxia-ischemia

decreased neuronal precursor cell number ( J:180177 )

• in the striatum following induction of hypoxia-ischemia

homeostasis/metabolism

abnormal DNA repair ( J:180177 )

• paraquat-treated neurospheres exhibit increased accumulation of strand breaks compared with wild-type cells

• however, brains do not accumulate double-strand breaks

increased cerebral infarct size ( J:180177 )

• 2.6-fold larger following induction of hypoxia-ischemia

immune system

decreased microglial cell activation ( J:180177 )

• decreased following induction of hypoxia-ischemia

cellular

abnormal neuron differentiation ( J:180177 )

• neurospheres exhibit poor growth and skewed differentiation compared with wild-type neurospheres

abnormal neuronal precursor proliferation ( J:180177 )

• decreased proliferation following induction of hypoxia-ischemia

abnormal DNA repair ( J:180177 )

• paraquat-treated neurospheres exhibit increased accumulation of strand breaks compared with wild-type cells

• however, brains do not accumulate double-strand breaks

hematopoietic system

decreased microglial cell activation ( J:180177 )

• decreased following induction of hypoxia-ischemia