Phenotypes for Tnfsf11 MGI:5307895 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Tnfsf11^tles/Tnfsf11^tm1Pngr
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfsf11^tles mutation (2 available); any Tnfsf11 mutation (32 available)
Tnfsf11^tm1Pngr mutation (0 available); any Tnfsf11 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

failure of tooth eruption ( J:179743 )

decreased osteoclast cell number ( J:179743 )

• absent

increased bone volume ( J:179743 )

abnormal trabecular bone morphology ( J:179743 )

• trabecular spacing is reduced compared to in wild-type mice

increased bone trabecula number ( J:179743 )

increased bone mass ( J:179743 )

osteopetrosis ( J:179743 )

• severe

immune system

decreased osteoclast cell number ( J:179743 )

• absent

craniofacial

failure of tooth eruption ( J:179743 )

hematopoietic system

decreased osteoclast cell number ( J:179743 )

• absent

growth/size/body

failure of tooth eruption ( J:179743 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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