Phenotypes for Bmp2 Bmp4 Bmp7 H2az2 MGI:5312868 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Bmp2^tm1Jfm/Bmp2^tm1Jfm Bmp4^tm1Jfm/Bmp4^tm1Jfm Bmp7^tm1Jfm/Bmp7^tm1Jfm H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2^tm1Jfm mutation (1 available); any Bmp2 mutation (27 available)
Bmp4^tm1Jfm mutation (1 available); any Bmp4 mutation (23 available)
Bmp7^tm1Jfm mutation (0 available); any Bmp7 mutation (37 available)
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

abnormal craniofacial bone morphology ( J:181229 )

• drastic reduction in most cranial neural crest derived bones

large anterior fontanelle ( J:181229 )

• enlarged frontal fontanelle at E18.5

• phenotype is more severe than in conditional null mice wild-type for Bmp2

abnormal interparietal bone morphology ( J:181229 )

• pieces of the interparietal bone are absent

absent alisphenoid bone ( J:181229 )

absent temporal bone squamous part ( J:181229 )

abnormal mandible morphology ( J:181229 )

• mandibular defects at E18.5

• phenotype is more severe than in conditional null mice wild-type for Bmp2

absent mandibular angle ( J:181229 )

absent mandibular condyloid process ( J:181229 )

absent mandibular coronoid process ( J:181229 )

absent maxilla ( J:181229 )

abnormal nasal bone morphology ( J:181229 )

• pieces of the nasal bone are absent

absent zygomatic bone ( J:181229 )

cleft palate ( J:181229 )

hearing/vestibular/ear

absent tympanic ring ( J:181229 )

skeleton

abnormal craniofacial bone morphology ( J:181229 )

• drastic reduction in most cranial neural crest derived bones

large anterior fontanelle ( J:181229 )

• enlarged frontal fontanelle at E18.5

• phenotype is more severe than in conditional null mice wild-type for Bmp2

abnormal interparietal bone morphology ( J:181229 )

• pieces of the interparietal bone are absent

absent alisphenoid bone ( J:181229 )

absent temporal bone squamous part ( J:181229 )

abnormal mandible morphology ( J:181229 )

• mandibular defects at E18.5

• phenotype is more severe than in conditional null mice wild-type for Bmp2

absent mandibular angle ( J:181229 )

absent mandibular condyloid process ( J:181229 )

absent mandibular coronoid process ( J:181229 )

absent maxilla ( J:181229 )

abnormal nasal bone morphology ( J:181229 )

• pieces of the nasal bone are absent

absent zygomatic bone ( J:181229 )

digestive/alimentary system

cleft palate ( J:181229 )

growth/size/body

abnormal nasal bone morphology ( J:181229 )

• pieces of the nasal bone are absent

cleft palate ( J:181229 )

respiratory system

abnormal nasal bone morphology ( J:181229 )

• pieces of the nasal bone are absent

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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