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Phenotypes Associated with This Genotype
Genotype
MGI:5314234
Allelic
Composition		 Syktm1.1Nns/Syktm1.1Nns
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background		 involves: C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation (4 available); any Commd10 mutation (25 available)
Syktm1.1Nns mutation (0 available); any Syk mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:181715 )
N
• unlike null homozygotes, mice survive to adulthood

immune system
abnormal lymphatic vessel morphology ( J:181715 )
• at E14.5, mice exhibit blood-filled vessels unlike control mice
• at 8 weeks, dye injection confirms interconnection between lymphatic and blood vessels with rapid spread labeling unlike in control mice

cardiovascular system
abnormal blood vessel morphology ( J:181715 )
• at 8 weeks, dye injection confirms interconnection between lymphatic and blood vessels with rapid spread labeling unlike in control mice

homeostasis/metabolism
edema ( J:181715 )
• at E14.5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory